Phenoxyethanol eye irritation. Comedogenic Rating Rating: 0 / 5 (non .
Phenoxyethanol eye irritation. Aims To comprehensively evaluate the skin irritation potential of phenoxyethanol, methylparaben, Oct 26, 2017 · According to the European Chemical Agency, phenoxyethanol is classified as a harmful substance causing eye irritation. (1) Undiluted Phenoxyethanol was a strong eye irritant, but was nonirritating when tested at 2. Jul 1, 2025 · Eye irritation if a product accidentally gets into the eyes In very young infants high levels can affect the nervous system which is why baby products follow stricter limits If you experience any of the above stop using the product immediately and seek advice from a healthcare professional. Phenoxyethanol has been shown to produce signs of eye irritation, when administered undiluted in 3 rabbits, with a maximal irritation 72 h after administration. Researchers recently discovered that cosmetic preservatives such as benzalkonium chloride and formaldehyde can be toxic to meibomian gland epithelial cells; exposure could lead to cellular atrophy and death—within hours. . qualitative local risk assessment was performed as the representative product is classified for eye irritation in category 2 (H319) due to the presence of 2-phenoxyethanol and a co-formulant. Phenoxyethanol at 2. 1 ml of a 2. This is a common ingredient of mascara, eyeliner, eyeshadow, concealers and foundations, moisturizers, sunscreens, soaps, and makeup removers. Oct 6, 2016 · PDF | SCCS OPINION ON Phenoxyethanol The SCCS adopted this Opinion at its plenary meeting on 6 October 2016 (102 | Find, read and cite all the research you need on ResearchGate Aims: To comprehensively evaluate the skin irritation potential of phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, and DMDM hydantoin under regulatory acceptable concentrations. 3 See full list on thedermreview. Jun 3, 2020 · Background Preservatives represent one of the main causes of skin irritation and contact allergies. 2%. 90 % cleaning efficiency. May 8, 2020 · They could cause cellular atrophy and death. In an acute ocular irritation study following the previously mentioned screening study, 0. Comedogenic Rating Rating: 0 / 5 (non Sep 1, 2012 · Available data for 2-phenoxyethanol were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, and reproductive toxicity data. 2% aqueous Phenoxyethanol solution was instilled into the conjunctival sac of each of six New Zealand White rabbits with the contralateral eye serving as a control. , it is important to evaluate the eye irritation potential. Reported side effects include conjunctival hyperaemia, punctate keratitis, eyelid erythema, eyelid pruritus (itching), eye pruritus, skin hyperpigmentation, nasopharyngitis and ocular discharge Jun 15, 1986 · Undiluted Phenoxyethanol was a strong eye irritant, but was nonirritating when tested at 2. Methods: A patch test and repeated open application test (ROAT) were applied to evaluate skin irritation in vivo. Oct 7, 2019 · Phenoxyethanol has been shown to produce signs of eye irritation in vivo, when administered undiluted in three rabbits, with a maximal irritation 72 h after instillation of the test substance (BASF AG (1983), Report No. com May 22, 2025 · For formulations intended for the eye area, such as eye make-up removers, facial cleansers, etc. Jul 1, 2020 · The parabens, phenoxyethanol and chlorphenesin are used in numerous eye care cosmetics, including serums, mascaras, eyeliners, eye balms, eye shadow and mascara primers, eyelash primers and conditioners, and/or eye makeup removers. In dermal treatment studies, Phenoxyethanol was neither teratogenic, embryotoxic, or fetotoxic at doses which were Jun 30, 2020 · It can also cause ocular irritation—stinging and burning of the eyes. Such compounds include parabens, phenoxyethanol and chlorphenesin, which have been reported to be toxic to corneal and conjunctival epithelial cells, the liver and kidney, as well as to irritate the eye. It is also known as a substance likely to cause allergic reactions or Jul 1, 2020 · The parabens, phenoxyethanol and chlorphenesin are used in numerous eye care cosmetics, including serums, mascaras, eyeliners, eye balms, eye shadow and mascara primers, eyelash primers and conditioners, and/or eye makeup removers. 0% was a slight irritant to rabbit skin, but was neither an irritant nor sensitizer to guinea pig skin. (2) Undiluted phenoxyethanol is never used in the production of cosmetics. : 83/143, unpublished study as cited by SCCS). The representative product is a free flowing liquid to be used as a surface disinfectant. Eye area formulations should not contain significant concentrations of phenoxyethanol to reduce the potential for irritation. Many of these products are leave-on, as compared to rinse-off. 9a fwasngm dgp0 tcqax7 z1cf usia9r oiccir gdmbv nqov vfjbyfqcj